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PubMed · 8790565

Interferon response pathways--a paradigm for cytokine signalling?

M Müller·H Ibelgaufts·I M Kerr
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Abstract

Considerable progress has been made in the past few years elucidating the molecular mechanisms of cytokine signalling. The interferons (IFNs) have provided a singular system allowing the detailed characterization of a specific cytokine signalling pathway. Studies on the IFN signal transduction pathway have identified protein tyrosine kinases (PTKs) that phosphorylate signal transducers (STATs) which then bind to DNA promoter sequences and activate gene transcription. Related work has shown that JAKs and STATs are also activated in response to a variety of the cytokines. Thus the novel type of signal transduction pathway identified for the IFNs promises to be more widely utilized than anticipated.

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AnimalsDNA-Binding ProteinsHumansInterferonsJanus Kinase 1Protein-Tyrosine KinasesSTAT2 Transcription FactorSignal TransductionTrans-ActivatorsTranscription FactorsJournal ArticleReview

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BibTeXRIS

M Müller, H Ibelgaufts, I M Kerr. 1994. Interferon response pathways--a paradigm for cytokine signalling?. https://doi.org/10.1111/j.1365-2893.1994.tb00109.x

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