Phosphoinositide kinases.

C L Carpenter; L C Cantley

doi:10.1016/s0955-0674(96)80060-3

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PubMed · 8791418

Phosphoinositide kinases.

C L Carpenter·L C Cantley

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Abstract

Recently, a number of cDNA clones with homology to the catalytic subunit of phosphoinositide 3-kinase have been identified, and the sequence of the first cDNA clone encoding a phosphatidylinositol 4-phosphate 5-kinase has been published. Use of both dominant-negative mutants of phosphoinositide 3-kinase and the inhibitors wortmannin and LY294002 has identified a number of processes in which phosphoinositide 3-kinase participates, including cell motility, the Ras pathway, vesicle trafficking and secretion, and apoptosis. Several possible biochemical targets of phosphoinositides have been found.

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C L Carpenter, L C Cantley. 1996. Phosphoinositide kinases.. https://doi.org/10.1016/s0955-0674(96)80060-3

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