RET oncogene.

Y F Mak; B A Ponder

doi:10.1016/s0959-437x(96)90015-5

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RET oncogene.

Y F Mak·B A Ponder

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Abstract

RET mutations have been identified as the underlying cause of two congenital diseases that predominately affect tissues of neural crest origin: the MEN 2 cancer syndromes and a proportion of cases of dominantly inherited Hirschsprung disease, a disorder of gut development. This review summarizes the disease-causing mutations and our present understanding of their possible effects on RET protein function.

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Animals Drosophila Proteins Hirschsprung Disease Humans Multiple Endocrine Neoplasia Type 2a Mutation Phenotype Proto-Oncogene Proteins Proto-Oncogene Proteins c-ret Receptor Protein-Tyrosine Kinases Journal Article Review

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Y F Mak, B A Ponder. 1996. RET oncogene.. https://doi.org/10.1016/s0959-437x(96)90015-5

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