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Does graft-versus-host disease attack epithelial stem cells?

G E Sale
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Abstract

Graft-versus-host disease (GvHD) is the opposite of graft rejection in that a transplant containing donor lymphocytes attacks the host's skin, liver and gut. This disease can usefully also attack host tumor cells. There is a peculiar distribution of normal tissue targets in epithelial stem cell sites, suggesting that GvHD may be the abnormal counterpart of a physiological growth control system. Efforts to understand how the graft-versus-tumor effect could be therapeutically separated from GvHD require further understanding of the mechanisms involved in GvHD.

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AnimalsGraft vs Host DiseaseHistocompatibility Antigens Class IIHumansKiller Cells, NaturalNeoplasmsStem CellsT-Lymphocytes, CytotoxicJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review

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BibTeXRIS

G E Sale. 1996. Does graft-versus-host disease attack epithelial stem cells?. https://doi.org/10.1016/1357-4310(96)88721-1

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