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PubMed · 8799975

Information processing by graded-potential transmission through tonically active synapses.

M Juusola·A S French·R O Uusitalo·M Weckström
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Abstract

Many neurons use graded membrane-potential changes, instead of action potentials, to transmit information. Traditional synaptic models feature discontinuous transmitter release by presynaptic action potentials, but this is not true for synapses between graded-potential neurons. In addition to graded and continuous transmitter release, they have multiple active zones, ribbon formations and L-type Ca2+ channels. These differences are probably linked to the high rate of vesicle fusion required for continuous transmitter release. Early stages of sensory systems provide some of the best characterized graded-potential neurons, and recent work on these systems suggests that modification of synaptic transmission by adaptation is a powerful feature of graded synapses.

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AnimalsNeuronsSynapsesSynaptic TransmissionJournal ArticleResearch Support, Non-U.S. Gov'tReview

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M Juusola, A S French, R O Uusitalo, M Weckström. 1996. Information processing by graded-potential transmission through tonically active synapses.. https://doi.org/10.1016/s0166-2236(96)10028-x

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