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PubMed · 8800837

Bacterial superantigens in human disease: structure, function and diversity.

R G Ulrich·S Bavari·M A Olson
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Abstract

All bacterial superantigens use common structural strategies to bind to major histocompatibility complex class II receptors, while binding the T cell antigen receptor in different ways. Overstimulation of the immune response is responsible for the acute pathological effects, while reactivation of developmentally silenced T cells might result in autoimmune disease. Certain diseases might be controlled with superantigens or genetically attenuated vaccines.

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Adjuvants, ImmunologicAnimalsAntigens, BacterialBacterial InfectionsBacterial VaccinesHumansSuperantigensT-LymphocytesJournal ArticleReview

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R G Ulrich, S Bavari, M A Olson. 1995. Bacterial superantigens in human disease: structure, function and diversity.. https://doi.org/10.1016/s0966-842x(00)89011-3

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