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PubMed · 8804836

Oligonucleotide directed triple helix formation.

J S Sun·T Garestier·C Hélène
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Abstract

Oligonucleotide directed triple helix formation allows the sequence-specific recognition of the major groove of double-helical DNA. Recently synthesized base analogs and backbones, such as N3'-->P5' phosphoramidates, allow stable triplexes to be formed under physiological conditions. However, it remains a challenge to design new oligomers that would extend the range of recognition sequences (which are still limited to oligopurine-rich tracts). Oligonucleotide directed triple helix formation could be used to control biological processes such as transcription and replication. Three-stranded structures formed during recombination processes have been further characterized.

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Base CompositionDNAKineticsNucleic Acid ConformationRNARec A RecombinasesThermodynamicsJournal ArticleReview

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J S Sun, T Garestier, C Hélène. 1996. Oligonucleotide directed triple helix formation.. https://doi.org/10.1016/s0959-440x(96)80051-0

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Application of CE for determination of DNA base composition.

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Base Composition↗