Two steps to binding replication origins? DNA-protein interactions.

F B Dean; M O'Donnell

doi:10.1016/s0960-9822(02)00629-2

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Two steps to binding replication origins? DNA-protein interactions.

F B Dean·M O'Donnell

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Abstract

Recent structural studies of the Epstein-Barr virus EBNA1 protein bound to DNA suggest that it binds to DNA replication origins in a two-step process; the first step involves recognition of the correct sequence and the second initiates structural changes in the DNA.

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DNA DNA-Binding Proteins Epstein-Barr Virus Nuclear Antigens Nucleic Acid Conformation Protein Binding Protein Conformation Replication Origin Journal Article Review

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F B Dean, M O'Donnell. 1996-08-01. Two steps to binding replication origins? DNA-protein interactions.. https://doi.org/10.1016/s0960-9822(02)00629-2

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