Finding a basis for flipping bases.

X Cheng; R M Blumenthal

doi:10.1016/s0969-2126(96)00068-8

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Finding a basis for flipping bases.

X Cheng·R M Blumenthal

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Abstract

Rotation of a DNA nucleotide out of the double helix and into a protein binding pocket ('base flipping') was first observed in the structure of a DNA methyltransferase. There is now evidence that a variety of proteins use base flipping in their interactions with DNA. Though the mechanism for base flipping is still unclear, we propose a three-step pathway: recognizing the target site and increasing the interstrand phosphate-phosphate distance nearby, initiating base flipping by protein invasion of the DNA, and trapping the flipped DNA structure.

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Amino Acid Sequence DNA DNA-Cytosine Methylases Deoxyribonuclease (Pyrimidine Dimer)Endodeoxyribonucleases Models, Molecular Molecular Sequence Data Nucleic Acid Conformation Nucleotides Protein Conformation Proteins Sequence Alignment Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Review

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X Cheng, R M Blumenthal. 1996-06-15. Finding a basis for flipping bases.. https://doi.org/10.1016/s0969-2126(96)00068-8

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