Attention and stimulus processing in the rat.

Abstract

There is little doubt that rats are an essential species in laboratory testing. Given the substantial amount of anatomical and pharmacological information which is available for this species, rats are the animal of choice for many initial neurobiological investigations of the basic mechanisms of learning and memory as well as for pharmacological screening. Indeed, the study of brain-behaviour interactions is greatly facilitated in the rat given the ease with which brain transmitter systems and structures can be selectively manipulated, in contrast to the technical difficulties involved in undertaking such techniques in non-human primates. However, when considering the processing of information that occurs during cognitive processes such as learning and memory it is important to remember that fundamental to such processes are mechanisms of attention. When considering the concept of attentional functioning, it is important to keep in mind that attention is not a unitary construct but consists of several distinct mechanisms: vigilance, divided attention and selective attention, not all of which have been adequately modelled in the rat. Furthermore, attentional processes are also involved in learning operant discrimination tasks and appear to be quite different from those involved in maintaining high levels of trained performance. Consideration of discrimination learning is important given that firstly, during such learning the animal must select from the environment those stimuli which are relevant and secondly, that this type of learning is obviously inherent in many other tests used to assess cognitive function, such as delayed matching-to-sample procedures. Such issues will therefore form the basis of the following discussion.