Requirement for invariant chain in B cell maturation and function.

I Shachar; R A Flavell

doi:10.1126/science.274.5284.106

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Requirement for invariant chain in B cell maturation and function.

I Shachar·R A Flavell

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Abstract

Previously the role of invariant chain (Ii) had been described only as a chaperone that facilitates folding and transport of major histocompatability complex class II molecules; here it is shown that Ii is required for B cell development. B cells from mice lacking Ii were found to have a low response to T-independent type II antigen and could not proliferate after the mice were injected with antigen. Study of cell surface markers revealed a developmental arrest that prevented immature virgin B cells from becoming mature B cells in the periphery. This block was independent of major histocompatability complex class II expression and was an intrinsic feature of B cells that correlated with the amount of Ii. Thus, Ii participates by an unknown mechanism in B cell maturation.

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Animals Antigens Antigens, Differentiation, B-Lymphocyte B-Lymphocytes Bone Marrow Cells Cells, Cultured Histocompatibility Antigens Class II Immunization Immunoglobulin D Immunoglobulin M Lymphocyte Activation Mice Mice, Knockout Mice, Transgenic Receptors, IgE Journal Article Research Support, Non-U.S. Gov't

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I Shachar, R A Flavell. 1996-10-04. Requirement for invariant chain in B cell maturation and function.. https://doi.org/10.1126/science.274.5284.106

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