Long loops in proteins.

A C Martin; K Toda; H J Stirk; J M Thornton

doi:10.1093/protein/8.11.1093

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PubMed · 8819975

Long loops in proteins.

A C Martin·K Toda·H J Stirk·J M Thornton

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Abstract

In proteins, loop regions which connect secondary structures are generally short (80% are <10 amino acids long). However, long loops, defined here as > or = 10 residues, do occur. Two types of long loop may be distinguished: those which connect adjacent regions of secondary structure ('long-closed') and those which connect distant secondary structures ('long-open'). Only 5% of all loops in proteins fall into the long-open class. Inspection of these unusual long-open loops reveals a higher percentage of proline residues and more helix-helix linkages than expected. Exposure to solvent is similar for long-open and long-closed loops. The role of these loops in protein folding is discussed.

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Amino Acid Sequence Animals Catalase Cattle Computer Simulation Databases, Factual Models, Molecular Molecular Sequence Data Protein Folding Protein Structure, Secondary Software Journal Article Research Support, Non-U.S. Gov't

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A C Martin, K Toda, H J Stirk, J M Thornton. 1995. Long loops in proteins.. https://doi.org/10.1093/protein%2F8.11.1093

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