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Myc-mediated apoptosis.

Y Kuchino·A Asai·C Kitanaka
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Abstract

Mammalian cells contain an intron-less myc gene, such as the rat s-myc gene and human myc L2 gene, which are expressed in rat embryo chondrocytes and human testis, respectively. Our recent findings demonstrated that s-Myc expression suppresses the growth activity and tumorigenicity of glioma cells, indicating that s-Myc acts as a negative regulator in tumor growth. In addition, we found that s-Myc overexpression can effectively induce apoptotic cell death in human and rat glioma cells without serum deprivation, which is distinct from c-Myc-mediated apoptosis.

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Amino Acid SequenceAnimalsApoptosisBase SequenceGenes, bcl-2Genes, mycHumansMolecular Sequence DataMultigene FamilyProto-Oncogene Proteins c-mycRatsJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Y Kuchino, A Asai, C Kitanaka. 1996. Myc-mediated apoptosis.. https://doi.org/10.1007/978-3-642-79850-4_7

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