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The staphylococcal insertion sequence IS257 is active.

C Needham·W C Noble·K G Dyke
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Abstract

The plasmid pJ3356 confers high-level mupirocin resistance on a strain of Staphylococcus aureus isolated from a hospital. The plasmid also carries two copies of IS257. Recombination of an IS257-containing plasmid conferring erythromycin resistance, pOX7-IS, into either of the IS257s of pJ3356 has been observed. The co-integration of pJ3356 and a small plasmid, pOX7, is also reported and involves duplication of one of the IS257s from pJ3356 together with 8 bp of pOX7 at the site of integration. Thus IS257 has been shown to be an active mobile genetic element.

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Base SequenceDNA PrimersDNA Transposable ElementsDNA, BacterialGene Expression Regulation, BacterialMolecular Sequence DataPlasmidsStaphylococcus aureusJournal ArticleResearch Support, Non-U.S. Gov't

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C Needham, W C Noble, K G Dyke. 1995. The staphylococcal insertion sequence IS257 is active.. https://doi.org/10.1006/plas.1995.0005

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