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PubMed · 883059

Anticoagulation in urologic surgery.

D B Halverstadt·D D Albers·R L Kroovand·R Rich
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Abstract

The present report describes a pilot project to apply the principle of minidose heparinization to patients undergoing prostatectomy, comparing a control group of 50 prostatectomies treated in conventional fashion to a study group of 43 prostatectomies treated with minidose heparinization. Results of the study indicate that perioperative minidose heparinization in patients undergoing prostatectomy is associated with longer hospitalization, greater need for blood transfusion, greater degree of immediate and delayed postoperative bleeding, and a higher incidence of "rebound" pulmonary embolization after cessation of heparin, than in patients treated in conventional fashion.

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HeparinHumansLength of StayMalePostoperative ComplicationsProstatectomyPulmonary EmbolismComparative StudyJournal Article

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D B Halverstadt, D D Albers, R L Kroovand, R Rich. 1977. Anticoagulation in urologic surgery.. https://doi.org/10.1016/0090-4295(77)90304-1

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Novel Pluronic/heparin composite nanocapsules that exhibit a thermally responsible swelling and deswelling behavior were synthesized. Pluronic F-127 preactivated with p-nitrophenyl chloroformate at its two terminal hydroxyl groups was dissolved in a methylene chloride phase. The organic phase was dispersed in an aqueous phase containing heparin. At an organic/aqueous interface, Pluronic-cross-linked heparin nanocapsules were produced. They exhibited a 1000-fold volume transition (ca. 336 nm at 25 degrees C; ca. 32 nm at 37 degrees C), and a reversible swelling and deswelling behavior when the temperature was cycled between 20 and 37 degrees C. The reversible volume transition of Pluronic nanocapsules was caused by micellization and demicellization of cross-linked Pluronic polymer chains within the nanocapsule structure in response to temperature. The morphological characters were investigated with transmission electron microscopy and small angle neutron scattering. Pluronic/heparin nanocapsules had an aqueous fluid-filled hollow interior with a surrounding shell layer below the critical temperature, but they became a collapsed core/shell structure similar to that of Pluronic micelles above it.

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