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Hypoketonaemic effect of L-alamine. Specific decrease in blood concentrations of 3-hydroxybutyrate in the rat.

P T Ozand·W D Reed·J Girard·R L Hawkins·R M Collins·J T Tildon·M Cornblath
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Abstract

1. The injection of L-alanine (50-100 mg/kg) into 35-day-old rats that had been starveed for 48 h increased blood L-alanine concentration to values observed in fed animals and lowered the blood concentration of 3-hydroxybutyrate within 2 min. 2. This hypoketon aemic action of L-alanine was specific for 3-hydroxybutyrate, since the acetoacetate concentrations did not change significantly. 3. The decrease in 3-hydroxybutyrate elicited by L-alanine was not related to changes in the blood concentrations of insulin, glucagon, growth hormone, glucose, unesterified fatty acids, lactate or pyruvate. 4. The injection of L-alanine resulted in a decrease in total ketones that was apparently unrelated to their increased peripheral utilization. These results are interpreted as an anti-ketogenic action of L-alanine. 5. The data suggest that L-alamine lowers ketone-body formation in starved rats, possibly via an alteration in hepatic redox equilibrium.

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AcetatesAcetoacetatesAlanineAnimalsBlood GlucoseFatty Acids, NonesterifiedFemaleHormonesHydroxybutyratesKetone BodiesLactatesMalePyruvatesRatsJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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P T Ozand, W D Reed, J Girard, R L Hawkins, R M Collins, J T Tildon, M Cornblath. 1977-06-15. Hypoketonaemic effect of L-alamine. Specific decrease in blood concentrations of 3-hydroxybutyrate in the rat.. https://doi.org/10.1042/bj1640557

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