Sequence-specific DNA recognition by peptide heterodimers.

M Sawada; Y Aizawa; M Ueno; T Morii; Y Sugiura

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PubMed · 8841592

Sequence-specific DNA recognition by peptide heterodimers.

M Sawada·Y Aizawa·M Ueno·T Morii·Y Sugiura

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Abstract

The DNA binding motif rich in basic amino acid residues is used by a variety of DNA binding proteins to recognize specific DNA sequences. We report here a sequence-specific DNA recognition by peptide heterodimers derived from the basic leucine zipper proteins. Specific hetero-dimerization is controlled by an artificial dimerization module consisting of a host-guest inclusion complex. Efficiency of the sequence discrimination by the peptide dimers depends on a stability of the half-matched binding complex. However, structures of the matched and half-matched binding complexes differ from one another.

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Base Sequence Binding Sites CCAAT-Enhancer-Binding Proteins DNA DNA-Binding Proteins Dimerization Fungal Proteins Leucine Zippers Models, Molecular Nuclear Proteins Nucleic Acid Conformation Peptides Protein Conformation Protein Kinases Saccharomyces cerevisiae Proteins Journal Article

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M Sawada, Y Aizawa, M Ueno, T Morii, Y Sugiura. 1995. Sequence-specific DNA recognition by peptide heterodimers.. https://pubmed.ncbi.nlm.nih.gov/8841592/

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