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PubMed · 8845544

Valproate in status epilepticus.

L M Holle·B E Gidal·D M Collins
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Abstract

In patients with intractable status epilepticus who have not responded to therapy with benzodiazepines, phenytoin, and barbiturates, valproate may be a reasonable option. Extemporaneously prepared valproate rectal suppositories or retention enemas have been given in dosages of 200-1200 mg q6h in addition to phenytoin, phenobarbital, or both in adults. The pediatric dose used was 15-20 mg/kg, in addition to phenytoin and/or phenobarbital.

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AnimalsAnticonvulsantsBiological AvailabilityClinical Trials as TopicDrug Evaluation, PreclinicalHumansStatus EpilepticusValproic AcidJournal Article

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L M Holle, B E Gidal, D M Collins. 1995. Valproate in status epilepticus.. https://doi.org/10.1177/106002809502901017

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