[Progress in vaccination against AIDS].

A Burny

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PubMed · 8845793

[Progress in vaccination against AIDS].

A Burny

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Abstract

Two vaccination trials against AIDS viruses are reported. The first trial was a prophylactic vaccination carried out in the pig-tailed macaque (Macacca nemestrina) against simian immunodeficiency virus (SIV) variant PBj14. The immunogen was a Semliki forest virus (SFV) recombinant expressing SFV - PBj14 envelope protein. Vaccination did not prevent infection but protected the animals against the disease (a fulminant form of AIDS that kills the animal within 12-15 days). The second trial was a therapeutic vaccination carried out with HIV-I-infected hemophilic patients. The immunogen was a toxoïd of alpha interferons. (A toxoïd of alpha interferons is an inactivated and immunogenic preparation of alpha interferons). Vaccination induced the production of neutralizing anti alpha interferon antibody. As a result, circulating alpha interferon concentrations were drastically lowered and the clinical status of patients significantly improved.

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AIDS Vaccines Acquired Immunodeficiency Syndrome Animals Humans Macaca nemestrina SAIDS Vaccines Simian Acquired Immunodeficiency Syndrome Clinical Trial English Abstract Journal Article Randomized Controlled Trial

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A Burny. 1995. [Progress in vaccination against AIDS].. https://pubmed.ncbi.nlm.nih.gov/8845793/

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