[The bacterial nucleoid].

M C Gómez-Eichelmann; R Camacho-Carranza

PubMed · 8850347

[The bacterial nucleoid].

Abstract

The bacterial genome is present in the cell within a complex structure, the nucleoid. The nucleoid contains the genomic DNA, and molecules of RNA and proteins. The main proteins of the nucleoid are: RNA polymerase, topoisomerases and the histone-like proteins: HU, H-NS (H1), H, HLP1, IHF and FIS. The DNA molecule in the nucleoid is under helical tension or supercoiling and is organized into 43 +/- 10 topodomains. DNA supercoiling is generated by the activity of the topoisomerases and by DNA-protein interactions. In this review, we analize current knowledge in Escherichia coli about genome organization and proteins of the nucleoid.

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Bacterial Proteins Cell Membrane Chromosomes, Bacterial DNA Topoisomerases, Type I DNA Topoisomerases, Type II DNA, Bacterial DNA, Superhelical DNA-Directed RNA Polymerases Escherichia coli Genome, Bacterial Histones Polyamines Journal Article Research Support, Non-U.S. Gov't Review

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M C Gómez-Eichelmann, R Camacho-Carranza. [The bacterial nucleoid].. https://pubmed.ncbi.nlm.nih.gov/8850347/

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