Development and expression of hormonal systems regulating aggression.

N G Simon; S E McKenna; S F Lu; A Cologer-Clifford

doi:10.1111/j.1749-6632.1996.tb32505.x

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Development and expression of hormonal systems regulating aggression.

N G Simon·S E McKenna·S F Lu·A Cologer-Clifford

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Abstract

There are multiple pathways involved in the regulation of male typical aggression by T, and the functional pathway is determined by genotype. Target-tissue sensitivity to the aggression-promoting properties of T and its estrogenic and androgenic metabolites is determined by a complex sequence of events in which steroid receptors play a critical role. To date, it appears that the relative density of AR may be an important factor in the biobehavioral effects of androgens. Regarding sensitivity to estrogens, characterization of ER-NM interactions, and understanding of the contribution of the two activating functions within ER, appears to be necessary to comprehensively describe the cellular basis for responsiveness to the aggression-promoting effect of this T metabolite. In broader terms, these observations indicate that understanding the relationship between T and the expression of aggression in humans will require models that incorporate cellular aspects of steroid hormone action, including metabolism, receptor function, and gene regulation.

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Aggression Animals Behavior, Animal Female Hormones Male Neural Pathways Sex Factors Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Review

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N G Simon, S E McKenna, S F Lu, A Cologer-Clifford. 1996-09-20. Development and expression of hormonal systems regulating aggression.. https://doi.org/10.1111/j.1749-6632.1996.tb32505.x

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