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PubMed · 8854083

Antigen-processing polymorphisms in chronic hepatitis C infection.

T Höhler·G Gerken·P M Schneider·K H Meyer zum Büschenfelde·C Rittner
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Abstract

BACKGROUND: Cytotoxic T cell (CTL) responses may influence the course of a hepatitis C infection. CTL recognize viral peptides on HLA class I molecules. Antigenic peptides for class I presentation are generated by proteasomes and transported into the endoplasmic reticulum by the TAP proteins. It is unknown whether polymorphisms of the antigen-processing genes might influence the development of chronic hepatitis C. METHODS: 75 patients with chronic hepatitis C and 99 unrelated controls were typed for TAP and LMP2 polymorphisms. Typing was done by allele-specific PCR techniques and PCR with subsequent single-stranded confirmation polymorphism (SSCP) analysis. RESULTS: Apart from minor increases of the TAP2*0101 allele and LMP2 heterozygotes in the chronic hepatitis group there were no statistically significant differences between the two groups. CONCLUSIONS: These findings suggest, that disease association for chronic hepatitis C does not extend beyond the HLA-DQ locus. Although TAP and LMP play an important role in the processing of viral antigens, their limited polymorphisms do not show any association with the development of chronic hepatitis C.

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ATP Binding Cassette Transporter, Subfamily B, Member 2ATP Binding Cassette Transporter, Subfamily B, Member 3ATP-Binding Cassette TransportersAllelesAmino Acid SequenceAntigen PresentationChronic DiseaseCysteine EndopeptidasesHepatitis CHumansMajor Histocompatibility ComplexPolymorphism, GeneticProteinsJournal Article

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T Höhler, G Gerken, P M Schneider, K H Meyer zum Büschenfelde, C Rittner. 1996. Antigen-processing polymorphisms in chronic hepatitis C infection.. https://pubmed.ncbi.nlm.nih.gov/8854083/

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