Interferon-gamma in autoimmunity.

A Billiau

doi:10.1016/1359-6101(96)00004-4

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Interferon-gamma in autoimmunity.

A Billiau

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Abstract

Autoimmune disorders are characterized by abrogation of self-tolerance, resulting in emergence of activated self-reactive lymphocyte clones that trigger or maintain inflammatory reactions in specific organs. Interferon-gamma (IFN-gamma), as well as other cytokines, plays an important role as a regulator of the activation of self-reactive lymphocytes and of bystander and accessory cells that are involved in the autoimmune inflammatory response. In experimental models of autoimmunity, endogenous IFN-gamma has invariably been found to profoundly affect the disease course. However, it acts in one way in some diseases and in the opposite way in others.

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Animals Antibody Formation Autoimmunity Disease Models, Animal Humans Interferon Inducers Interferon-gamma Organ Specificity Th1 Cells Journal Article Research Support, Non-U.S. Gov't Review

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A Billiau. 1996. Interferon-gamma in autoimmunity.. https://doi.org/10.1016/1359-6101(96)00004-4

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