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Intraseptal microinjection of beta-funaltrexamine blocked a microwave-induced decrease of hippocampal cholinergic activity in the rat.

H Lai·M A Carino·A Horita·A W Guy
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Abstract

Acute (45 min) exposure to pulsed (2 microseconds pulse width, 500 pulses per second) 2450-MHz microwaves at a power density of 1 mW/cm2 (whole body specific absorption rate 0.6 W/kg) microwaves caused a decrease in cholinergic activity in the hippocampus of the rat as measured by the sodium-dependent high-affinity choline uptake. Microinjection of beta-funaltrexamine (1 microgram) into the septum before microwave exposure blocked this effect. These data indicate that mu-opioid receptors in the septum mediate a microwave-induced decrease in cholinergic activity in the hippocampus and support our hypothesis that microwaves at a whole body SAR of 0.6 W/kg can activate endogenous opioids in the brain.

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AnimalsCholineCholinergic FibersHippocampusMaleMicroinjectionsNaltrexoneNarcotic AntagonistsRatsRats, Sprague-DawleyJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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H Lai, M A Carino, A Horita, A W Guy. 1996. Intraseptal microinjection of beta-funaltrexamine blocked a microwave-induced decrease of hippocampal cholinergic activity in the rat.. https://doi.org/10.1016/0091-3057(95)02058-6

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