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Pattern formation in the immortal Hydra.

W A Müller
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Abstract

Well-documented experimental studies with Hydra, done 10-20 years before Mozart was born, marked the dawn of modern developmental biology. Since those days, the immortal and perpetually embryonic hydra has been a classic model system, but despite its deceptively simple appearance, hydra has not yielded its secrets readily. Recent evidence points to a pivotal role of PI-PKC-type signal transduction pathways in morphogenesis: interference with these pathways results in polyps with multiple heads or feet. While molecular techniques are revealing genes involved in pattern realization, a new model of pattern regulation, based on competition for hormonal factors by autoregulatory receptors, emphasizes epigenetic interactions.

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AnimalsGene Expression Regulation, DevelopmentalHydraModels, BiologicalSignal TransductionStem CellsJournal ArticleReview

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W A Müller. 1996. Pattern formation in the immortal Hydra.. https://doi.org/10.1016/0168-9525(96)81419-3

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