Ischemic neuronal damage. How does mild hypothermia modulate it?

K Kataoka; A Mitani; H Yanase; L Zhang; M Higashihara; T Ogata; K Tsuji; Y Nakamura; A McRae; K Ogita; Y Yoneda

doi:10.1007/bf02815222

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Ischemic neuronal damage. How does mild hypothermia modulate it?

K Kataoka·A Mitani·H Yanase·L Zhang·M Higashihara·T Ogata·K Tsuji·Y Nakamura·A McRae·K Ogita·Y Yoneda

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Abstract

The significance of mild hypothermia as a therapeutic measure for ischemic brain damage is presented on the basis of different experimental results. An extracellular glutamate surge, a sustained activation of N-methyl-D-aspartate (NMDA) receptors, and an enhancement of DNA binding activity to transcription factor AP-1, all being key items directly linked to excitotoxic neuronal damage, are deeply affected by slightly lowering temperature (mild hypothermia [MH]). The cellular mechanism of MH seems rather nonspecific but tends to collectively involve these key items rendering neurons resistant to ischemic damage. Clinical application of MH should be a great challenge to relieve deadly effects on central neurons.

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Animals Brain Brain Ischemia DNA DNA-Binding Proteins Glutamic Acid Humans Hypothermia, Induced Neurons Receptors, N-Methyl-D-Aspartate Transcription Factor AP-1 Journal Article Review

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K Kataoka, A Mitani, H Yanase, L Zhang, M Higashihara, T Ogata, K Tsuji, Y Nakamura, A McRae, K Ogita, Y Yoneda. Ischemic neuronal damage. How does mild hypothermia modulate it?. https://doi.org/10.1007/bf02815222

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