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PubMed · 8879990

Insulin as a growth factor.

R K Menon·M A Sperling
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Abstract

Various clinical syndromes illustrate the essential role of insulin in modulating somatic growth both in utero and after birth. The effect of insulin on growth is a consequence of direct effects transduced via its homologous receptor and post-receptor signaling pathways and indirect effects on other modulators of growth, such as the growth hormone-IGF axis. Recent insights into the post-receptor mechanisms of insulin signaling provide a scientific framework for the distinction between the traditional role of insulin as a major modulator of metabolism and its role as a promoter of growth.

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AnimalsEmbryonic and Fetal DevelopmentGrowthHumansInsulinJournal ArticleReview

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BibTeXRIS

R K Menon, M A Sperling. 1996. Insulin as a growth factor.. https://doi.org/10.1016/s0889-8529(05)70344-3

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