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PubMed · 8882503

Bootstrap method of interior-branch test for phylogenetic trees.

T Sitnikova
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Abstract

Statistical properties of the bootstrap test of interior branch lengths of phylogenetic trees have been studied and compared with those of the standard interior-branch test in computer simulations. Examination of the properties of the tests under the null hypothesis showed that both tests for an interior branch of a predetermined topology are quite reliable when the distribution of the branch length estimate approaches a normal distribution. Unlike the standard interior-branch test, the bootstrap test appears to retain this property even when the substitution rate varies among sites. In this case, the distribution of the branch length estimate deviates from a normal distribution, and the standard interior-branch test gives conservative confidence probability values. A simple correction method was developed for both interior-branch tests to be applied for testing the reliability of tree topologies estimated from sequence data. This correction for the standard interior-branch test appears to be as effective as that obtained in our previous study, though it is much simpler. The bootstrap and standard interior-branch tests for estimated topologies become conservative as the number of sequence groups in a star-like tree increases.

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AnimalsComputer SimulationHumansPhylogenyStatistics as TopicJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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T Sitnikova. 1996. Bootstrap method of interior-branch test for phylogenetic trees.. https://doi.org/10.1093/oxfordjournals.molbev.a025620

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