Proteasomes: destruction as a programme.

W Hilt; D H Wolf

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PubMed · 8882582

Proteasomes: destruction as a programme.

W Hilt·D H Wolf

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Abstract

Proteasomes are large multi-subunit protease complexes that selectively degrade intracellular proteins. Most of the proteins removed by these proteases are tagged for destruction by ubiquitination. Proteasomes have a role to play in controlling cellular processes, such as metabolism and the cell cycle, through signal-mediated proteolysis of key enzymes and regulatory proteins. They also operate in the stress response, by removing abnormal proteins, and in the immune response, by generating antigenic peptides.

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Animals Antigen Presentation Cell Cycle Cysteine Endopeptidases Humans Immunity Models, Molecular Multienzyme Complexes Proteasome Endopeptidase Complex Proteins Stress, Physiological Ubiquitins Journal Article Research Support, Non-U.S. Gov't Review

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W Hilt, D H Wolf. 1996. Proteasomes: destruction as a programme.. https://pubmed.ncbi.nlm.nih.gov/8882582/

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