Distance distributions in proteins: a six-parameter representation.

M G Reese; O Lund; J Bohr; H Bohr; J E Hansen; S Brunak

doi:10.1093/protein/9.9.733

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Distance distributions in proteins: a six-parameter representation.

M G Reese·O Lund·J Bohr·H Bohr·J E Hansen·S Brunak

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Abstract

We present a statistical analysis of protein structures based on interatomic C alpha distances. The overall distance distributions reflect in detail the contents of sequence-specific substructures maintained by local interactions (such as alpha-helixes) and longer range interactions (such as disulfide bridges and beta-sheets). We also show that a volume scaling of the distances makes distance distributions for protein chains of different length superimposable. Distance distributions were also calculated specifically for amino acids separated by a given number of residues. Specific features in these distributions are visible for sequence separations of up to 20 amino acid residues. A simple representation, which preserves most of the information in the distance distributions, was obtained using six parameters only. The parameters give rise to canonical distance intervals and when predicting coarse-grained distance constraints by methods such as data-driven artificial neural networks, these should preferably be selected from these intervals. We discuss the use of the six parameters for determining or reconstructing 3-D protein structures.

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Amino Acid Sequence Amino Acids Databases, Factual Molecular Structure Protein Conformation Protein Engineering Protein Folding Protein Structure, Secondary Proteins Journal Article Research Support, Non-U.S. Gov't

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M G Reese, O Lund, J Bohr, H Bohr, J E Hansen, S Brunak. 1996. Distance distributions in proteins: a six-parameter representation.. https://doi.org/10.1093/protein%2F9.9.733

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