Clozapine-induced cognitive dysfunction in mice.

I Ninan; S K Kulkarni

PubMed · 8892266

Clozapine-induced cognitive dysfunction in mice.

Abstract

The atypical antipsychotic clozapine was examined for its ability to interrupt cognitive functions in mice on passive avoidance paradigm and elevated plus maze. The posttraining intraperitoneal injection of clozapine (0.1-7.5 mg/kg) induced dysfunction in acquisition as well as retrieval, which was reversed by physostigmine (0.05 mg/kg). Clozapine showed dose-related effects on scopolamine-induced cognitive dysfunction, with higher doses having no significant effect and lower doses reversing the dysfunction. These results are explained on the basis of clozapine's effects on central cholinergic receptors.

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Animals Antipsychotic Agents Avoidance Learning Clozapine Disease Models, Animal Dose-Response Relationship, Drug Drug Interactions Drug Synergism Electric Stimulation Injections, Intraperitoneal Maze Learning Mice Muscarinic Antagonists Scopolamine Journal Article

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I Ninan, S K Kulkarni. Clozapine-induced cognitive dysfunction in mice.. https://pubmed.ncbi.nlm.nih.gov/8892266/

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