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PubMed · 8892523

Mitochondrial dysfunction after fetal alcohol exposure.

J Marin-Garcia·R Ananthakrishnan·M J Goldenthal
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Abstract

Specific mitochondrial enzyme activities and mRNA levels were measured in the heart, brain, and liver tissues of a group of 1-day-old neonatal rats whose mothers were alcohol-fed during pregnancy and compared with a control group. The results show a significant decrease in mitochondrial ATP synthase activity in both the brain and liver, as well as a decrease in complex III activity in the liver of rats exposed to alcohol. Other mitochondrial enzymes activities (e.g., citrate synthase, cytochrome c oxidase, and complex I), as well as specific mitochondrial transcript levels, were not significantly affected. Heart mitochondrial enzyme activities were not significantly affected. These data reveal that a tissue-specific response occurs after fetal exposure to alcohol and may explain some of the cellular events occurring in fetal alcohol syndrome resulting in abnormal growth and neurological development.

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ATP Synthetase ComplexesAnimalsAnimals, NewbornBrainCitrate (si)-SynthaseDNA ProbesDNA, MitochondrialElectron Transport Complex IIIElectron Transport Complex IVFemaleFetal Alcohol Spectrum DisordersMitochondriaMitochondria, HeartMitochondria, LiverMultienzyme ComplexesNAD(P)H Dehydrogenase (Quinone)Oxidative PhosphorylationPhosphotransferases (Phosphate Group Acceptor)PregnancyRatsRats, Sprague-DawleyJournal ArticleResearch Support, Non-U.S. Gov't

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J Marin-Garcia, R Ananthakrishnan, M J Goldenthal. 1996. Mitochondrial dysfunction after fetal alcohol exposure.. https://doi.org/10.1111/j.1530-0277.1996.tb01942.x

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