Ribonuclease P structure and function in Archaea.

J W Brown; E S Haas

doi:10.1007/bf00988717

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Ribonuclease P structure and function in Archaea.

J W Brown·E S Haas

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Abstract

An important approach to understanding RNA-based catalytic function by ribonuclease P is the investigation of its evolutionary diversity in structure and function. Because RNase P enzymes from all organisms are thought to share common ancestry, the fundamental features of structure and biochemistry should be conserved in all of its modern forms. In contrast to the bacterial enzyme, the RNase P enzymes from Eucarya, organelles, and Archaea are poorly understood. This review describes our nascent understanding of the structure and function of RNase P in Archaea, and how this enzyme compares to its homologs in the other evolutionary Domains.

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Archaea Base Sequence Endoribonucleases Evolution, Molecular Molecular Sequence Data Nucleic Acid Conformation RNA, Bacterial RNA, Catalytic Ribonuclease P Sequence Homology, Nucleic Acid Comparative Study Journal Article Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Review

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J W Brown, E S Haas. Ribonuclease P structure and function in Archaea.. https://doi.org/10.1007/bf00988717

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