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PubMed · 8901509

tRNA processing in human mitochondrial disorders.

J P Masucci·E A Schon
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Abstract

Many human mitochondrial disorders are associated with mutations in tRNA genes or with deletions of regions containing tRNA genes, all of which may be suspected to play a role in recognition by RNase P. Here we describe the analysis of five such mutations. The results presented here demonstrate that none of these mutations result in errors in RNase P function. Further studies of mutations in tRNAs need to be pursued to elucidate the identity elements for RNase P function in mammalian mitochondria.

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AnimalsBase SequenceDNA, MitochondrialEndoribonucleasesHumansMammalsMitochondriaMitochondrial MyopathiesMolecular Sequence DataMutationNucleic Acid ConformationRNA, CatalyticRNA, TransferRibonuclease PSequence DeletionTranscription, GeneticJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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J P Masucci, E A Schon. tRNA processing in human mitochondrial disorders.. https://doi.org/10.1007/bf00988727

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