Chimerism and central tolerance.

M Sykes

doi:10.1016/s0952-7915(96)80088-4

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Chimerism and central tolerance.

M Sykes

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Abstract

With adequate depletion or inactivation of the pre-existing immune system and establishment of conditions permitting donor hematopoietic stem cell engraftment, a robust state of central deletional tolerance to allogeneic or xenogeneic donors can be induced. Advances have been made in the ability to achieve this permissive state without toxic, myeloablative conditioning, thus bringing this approach closer to clinical application.

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Animals Chimera Graft Survival Hematopoietic Stem Cell Transplantation Humans Immune Tolerance Lymphocyte Depletion T-Lymphocytes Thymus Gland Transplantation Conditioning Transplantation, Heterologous Transplantation, Homologous Journal Article Review

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M Sykes. 1996. Chimerism and central tolerance.. https://doi.org/10.1016/s0952-7915(96)80088-4

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