Beta-2-microglobulin-associated amyloidosis.

J Floege; G Ehlerding

doi:10.1159/000188801

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Beta-2-microglobulin-associated amyloidosis.

J Floege·G Ehlerding

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Abstract

beta2-Microglobulin-associated amyloidosis has emerged as a major complication of long-term renal replacement therapy. The syndrome is confined to those patients on nontransplant modes of therapy. It does not occur in patients with a functioning renal transplant or, if already present, it does not progress any further in such patients. In the population of ESRD patients on dialysis, beta2-microglobulin-associated amyloidosis affects most patients treated for more than 15 years and is a cause of significant morbidity and in rare cases even mortality. The present review, which is based on the presentation of a typical case, discusses the current knowledge on the pathogenesis, clinical manifestations, diagnosis, prevention and therapy of beta2-microglobulin-associated amyloidosis.

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Amyloid Amyloidosis Humans Immunohistochemistry Kidney Failure, Chronic Kidney Transplantation Magnetic Resonance Imaging Male Microscopy, Electron Middle Aged Osteoarthropathy, Secondary Hypertrophic Radionuclide Imaging Renal Dialysis Uremia X-Rays beta 2-Microglobulin Case Reports Journal Article Research Support, Non-U.S. Gov't

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J Floege, G Ehlerding. 1996. Beta-2-microglobulin-associated amyloidosis.. https://doi.org/10.1159/000188801

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