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PubMed · 8904212

[Na+/H+ exchanger].

M Kuro-o
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Abstract

Recent investigations have revealed that an enhancement of Na+/H+ exchange activity is a frequently observed ion transport abnormality in hypertensive patients. To test the hypothesis that increased Na+/H+ exchange causes hypertension, we produced transgenic mice overexpressing Na+/H+ exchanger and analyzed their Na+ metabolism and blood pressure. Urinary excretion of water and Na+ was significantly decreased in transgenic mice and systolic blood pressure was elevated after salt loading. The impaired Na+ excretion suggested that the Na+/H+ exchanger overexpressed in the renal tubules increased Na+ reabsorption, which caused a blood pressure elevation by Na+ retention after excessive salt intake. Our results demonstrate that overexpression of Na+/H+ exchanger can be a genetic factor for salt-sensitive hypertension.

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AnimalsHumansHypertensionMiceMice, TransgenicSodiumSodium-Hydrogen ExchangersJournal ArticleReview

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M Kuro-o. 1996. [Na+/H+ exchanger].. https://pubmed.ncbi.nlm.nih.gov/8904212/

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