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PubMed · 8904213

[Na+ -Ca2+ exchanger].

T Matsuda·K Takuma·A Baba
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Abstract

Na+ -Ca2+ exchanger couples the translocation of Na+ in one direction with that of Ca2+ in the opposite direction, and it is considered to have an important role in Ca2+ homeostasis in several cells. There are two types of Na+ -Ca2+ exchangers (cardiac and rod outer segment types). The cardiac clone (NCX1) is modeled to have an amino-terminal cleaved signal sequence, 11 transmembrane segments, and a large hydrophilic cytoplasmic domain. Several isoforms generated by alternative splicing of NCX1 and an isoform (NCX2), a product of a different gene, are present in different tissues. This brief review focuses on the physiological importance, molecular aspects and the pathological roles of the exchanger, especially NCX1.

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Amino Acid SequenceAnimalsAntiportersCalciumHumansMolecular Sequence DataMyocardiumSodiumEnglish AbstractJournal ArticleReview

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T Matsuda, K Takuma, A Baba. 1996. [Na+ -Ca2+ exchanger].. https://pubmed.ncbi.nlm.nih.gov/8904213/

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