Tachykinin NK2 receptor antagonists decrease eicosanoid release in lung anaphylaxis.

P Montuschi; D Currò; G Ciabattoni

doi:10.1016/0014-2999(96)00545-6

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Tachykinin NK2 receptor antagonists decrease eicosanoid release in lung anaphylaxis.

P Montuschi·D Currò·G Ciabattoni

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Abstract

Two tachykinin NK2 receptor antagonists, MEN 10.627 c(Met-Asp-Trp-Phe-Dap-Leu) and MEN 10.376 [(Tyr5,Trp6,8,9,Lys10]neurokinin A-(4-10), were used to investigate the role of tachykinins in in vitro guinea-pig lung anaphylaxis. Both antagonists dose-dependently decreased bronchoconstriction and the release of thromboxane and prostaglandin E2 induced by antigen challenge in perfused sensitized lungs, but neither had any effect on the basal release of either eicosanoid. The findings indicated that tachykinins released by sensory nerve fibers may contribute to anaphylactic reactions by increasing arachidonic acid metabolite release.

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Anaphylaxis Animals Bronchoconstriction Dinoprostone Dose-Response Relationship, Drug Guinea Pigs In Vitro Techniques Lung Muscle, Smooth Neurokinin A Peptide Fragments Peptides, Cyclic Receptors, Tachykinin Thromboxane B2 Journal Article Research Support, Non-U.S. Gov't

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P Montuschi, D Currò, G Ciabattoni. 1996-10-10. Tachykinin NK2 receptor antagonists decrease eicosanoid release in lung anaphylaxis.. https://doi.org/10.1016/0014-2999(96)00545-6

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