Subcellular distribution, a factor in risk evaluation of pentachlorophenol.

E Arrhenius; L Renberg; L Johansson

doi:10.1016/0009-2797(77)90138-7

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Subcellular distribution, a factor in risk evaluation of pentachlorophenol.

E Arrhenius·L Renberg·L Johansson

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Abstract

Pentachlorophenol (PCP) is a potent uncoupler of mitochondrial phosphorylation in vitro and also interferes with microsomal detoxication functions in vitro. This favours flavin mediated oxygenation compared with flavin cytochrome P-450 dependent reactions. Gas chromatographic analysis of subcellular fractions, obtained by zonal centrifugation showed markedly lower PCP concentration in mitochondria and a high accumulation in microsomes compared with cytosol. This increases the likelihood that PCP in vivo causes a malfunction in microsomal detoxication.

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Acetylation Animals Cell-Free System Centrifugation, Zonal Chlorophenols Chromatography, Gas Cytosol In Vitro Techniques Liver Lysosomes Male Methylation Microsomes, Liver Mitochondria, Liver Pentachlorophenol Rats Risk Subcellular Fractions Journal Article

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E Arrhenius, L Renberg, L Johansson. 1977. Subcellular distribution, a factor in risk evaluation of pentachlorophenol.. https://doi.org/10.1016/0009-2797(77)90138-7

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