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PubMed · 8910959

Sequentially balanced three-squares cross-over designs.

R G Newcombe
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Abstract

Many cross-over designs with t > or = 2 treatments and periods and n = bt subjects (b an integer > or = 1) which incorporate balance for first-order carry-over effects are already known: single squares with any even value of t and some odd ones also; and sequentially balanced pairs of squares for any odd t > or = 3. We describe the construction of designs with b = 3, for t < or = 5, 7, 9, .... This permits use of sequentially balanced designs for any combination of b > 1 and t, except for b = t = 3, for which no such design exists.

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R G Newcombe. 1996-10-30. Sequentially balanced three-squares cross-over designs.. https://doi.org/10.1002/(sici)1097-0258(19961030)15%3A20%3C2143%3A%3Aaid-sim377%3E3.0.co%3B2-d

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