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Case report: multiple systemic lymph node metastases from a small hepatocellular carcinoma.

H Toyoda·Y Fukuda·Y Koyama·D Nishimura·H Hoshino·N Katada·K Kato·T Hayakawa
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Abstract

Extrahepatic lymph node metastases from hepatocellular carcinoma (HCC) are usually observed in patients with advanced and poorly differentiated HCC. We encountered a patient with multiple, systemic lymph node metastases from a small HCC (18 mm in diameter), which was nodular and had a capsule at the time of resection (a partial hepatectomy of the postero-inferior subsegment of the right lobe of the liver). Widespread lymphadenopathy resembling malignant lymphoma developed 2 months after surgery. A biopsy specimen from a supraclavicular lymph node revealed metastatic HCC. The patient died 2.5 months after the detection of the lymphadenopathy. Lymph node metastases can occur in small HCC less than 2 cm in diameter and may adversely affect the long-term prognosis of patients with these curatively resectable small HCC.

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Antineoplastic Combined Chemotherapy ProtocolsCarcinoma, HepatocellularHepatectomyHumansLiver NeoplasmsLymph NodesLymphatic MetastasisMaleMiddle AgedPrognosisTime FactorsCase ReportsJournal Article

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H Toyoda, Y Fukuda, Y Koyama, D Nishimura, H Hoshino, N Katada, K Kato, T Hayakawa. 1996. Case report: multiple systemic lymph node metastases from a small hepatocellular carcinoma.. https://doi.org/10.1111/j.1440-1746.1996.tb01854.x

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