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AIDS lymphoma.

A S Sandler·L Kaplan
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Abstract

Most AIDS-related non-Hodgkin's lymphomas can be categorized into one of three histologic subtypes: large-cell immunoblastic, small non-cleaved cell (Burkitt's or Burkitt's-like) and diffuse large cell. Rare histologies include Ki-1 anaplastic large cell lymphoma, angiotropic large cell lymphoma, mucosa-associated lymphoid tissue, primary pulmonary T-cell lymphoma, and Sézary syndrome. Although the role of Epstein-Barr virus remains uncertain, a new herpes virus, human herpes virus 8, has been identified in the rare subset of effusion-based lymphomas. Overexpression of the cytokines interleukin-6 and interleukin-10 may have a role in pathogenesis, and they may serve as potential therapeutic targets. In addition, chronic antigenic stimulation may correlate with elevated serum CD22 levels and may serve as a tool for early detection. Novel investigational therapies in clinical development include new chemotherapy-based regimens, immune modulators, antibody therapy, as well as cellular therapy.

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Antineoplastic AgentsCytokinesEnzyme InhibitorsHumansImmunologic FactorsImmunotherapyLymphoma, AIDS-RelatedLymphoma, Non-HodgkinJournal ArticleReview

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A S Sandler, L Kaplan. 1996. AIDS lymphoma.. https://doi.org/10.1097/00001622-199609000-00008

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