Systemic sclerosis. A vascular perspective.

E C LeRoy

doi:10.1016/s0889-857x(05)70295-7

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Systemic sclerosis. A vascular perspective.

E C LeRoy

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Abstract

The horizon is bright for SSc in a vascular context. Surrogate markers can now be routinely used in the management of the active patient; new cytokines, such as VEGF, can be studied along with the known abnormalities of the cytokine cascade (TGF beta 1, PDGF) for a more integrated understanding of the vascular pathogenesis of SSc (Fig. 6); and combination therapies can be applied before vascular insufficiency leads to vital organ failure. Thus, despite reimbursement and research funding constraints, the future for both the SSc patient and the investigator of SSc is optimistic when based on a firm biologic foundation.

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Arteries Autoantibodies Cell Adhesion Molecules Endothelium, Vascular Humans Mast Cells Microcirculation Neovascularization, Physiologic Raynaud Disease Scleroderma, Systemic T-Lymphocytes Vascular Diseases Journal Article Review

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E C LeRoy. 1996. Systemic sclerosis. A vascular perspective.. https://doi.org/10.1016/s0889-857x(05)70295-7

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