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Raynaud's phenomenon.

F M Wigley·N A Flavahan
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Abstract

Raynaud's phenomenon is a common clinical problem occurring in 3% to 5% of the general population. The first symptom of scleroderma is often Raynaud's phenomenon, which is associated with a diffuse small vessel vasculopathy and ischemia and reperfusion injury to skin and other organs targeted in this disease. Current studies support the concept that Raynaud's phenomenon is secondary to a local defect in the regulation of regional blood flow. New evidence demonstrates that there is a profound sensitivity to alpha 2-adrenoceptors mediated vasoconstriction in scleroderma vessels. Traditional treatment of Raynaud's phenomenon is cold avoidance and the use of vasodilators. Oral prostaglandins have shown promise as therapeutic agents.

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Clinical Trials as TopicHumansMicrocirculationProstaglandinsRaynaud DiseaseScleroderma, SystemicJournal ArticleReview

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BibTeXRIS

F M Wigley, N A Flavahan. 1996. Raynaud's phenomenon.. https://doi.org/10.1016/s0889-857x(05)70300-8

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