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PubMed · 8931927

New amino-nitroxide spin labels.

H Dragutan·A Caragheorgheopol·F Chiraleu·R J Mehlhorn
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Abstract

Stable free mono- and diradicals containing reactive primary or secondary amino groups in the side-chain have been synthesized by transesterification of amino-substituted esters with paramagnetic alcohols or from spin-labeled acid derivatives and amines. In the second approach the new radical 18 (1-oxyl-3-(2-bromoethoxycarbonyl)-2,2,5,5-tetramethylpyrroline) is proposed as an efficient alkylating species. The nitroxides described are pH-sensitive spin probes and spin labels potentially useful for a diversity of ESR applications in chemistry and biology. New spin-labeled tyramine 16 (N-(1-oxyl-3-carbonyl-2,2,5,5-tetramethyl-pyrroline)tyramine) was successfully employed in a novel assay of protein oxidative damage.

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Cyclic N-OxidesElectron Spin Resonance SpectroscopyFree RadicalsNitrogen OxidesSpin LabelsJournal Article

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BibTeXRIS

H Dragutan, A Caragheorgheopol, F Chiraleu, R J Mehlhorn. 1996. New amino-nitroxide spin labels.. https://doi.org/10.1016/0968-0896(96)00150-2

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