Ca-ATPase and bone cell mineralization.

J Abramowitz; W N Suki

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PubMed · 8933504

Ca-ATPase and bone cell mineralization.

J Abramowitz·W N Suki

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Abstract

The plasma membrane Ca-ATPases play an important role in the regulation of intracellular Ca2+ ion concentration by pumping Ca2+ out of the cell into the extracellular fluid at the expense of ATP. These pumps potentially play an important role in the delivery of Ca2+ during mineralization of hard tissues such as bone. The properties of the plasma membrane Ca2+ pump are compared with those of the sarco(endo)plasmic reticulum and the factors regulating pump function are presented. The different gene products for the plasma membrane Ca-ATPases are described as well as their known functional significance. Particular attention is paid on the plasma membrane Ca2+ pumps present in mineralizing tissues and evidence supporting a role for these pumps in the transcellular delivery of Ca2+ during the process of mineralization is also presented.

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Animals Biological Transport Bone and Bones Calcification, Physiologic Calcium-Transporting ATPases Cell Membrane Endoplasmic Reticulum Journal Article Review

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J Abramowitz, W N Suki. 1996. Ca-ATPase and bone cell mineralization.. https://pubmed.ncbi.nlm.nih.gov/8933504/

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