ICE-like proteases execute the neuronal death program.

J C Martinou; R Sadoul

doi:10.1016/s0959-4388(96)80092-4

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ICE-like proteases execute the neuronal death program.

J C Martinou·R Sadoul

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Abstract

The past year has witnessed significant advances in our understanding of the mechanisms that kill neurons during programmed cell death. The executioners are members of a family of proteases founded by ced-3, the product of a gene that is required for programmed cell death in the nematode Caenorhabditis elegans, and by mammalian interleukin-1 beta-converting enzyme. These proteases represent interesting novel targets for the therapy of acute and chronic pathologies of the nervous system associated with neuronal death.

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Amino Acid Sequence Animals Apoptosis Binding Sites Caenorhabditis elegans Calpain Caspase 1 Cysteine Endopeptidases Enzyme Activation Mammals Models, Neurological Multienzyme Complexes Neurons Proteasome Endopeptidase Complex Journal Article Review

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J C Martinou, R Sadoul. 1996. ICE-like proteases execute the neuronal death program.. https://doi.org/10.1016/s0959-4388(96)80092-4

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