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PubMed · 8939653

Extracellular calcium-binding proteins.

P Maurer·E Hohenester·J Engel
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Abstract

Point mutations in Ca2+-binding sites of extracellular matrix proteins have been identified as the cause of human disorders such as Marfansyndrome and pseudoachondroplasia. Although the modes of Ca2+ binding and the effects of point mutations are not yet understood in these two cases, new insight was recently gained by X-ray and NMR structure determinations of several other extracellular proteins; these studies revealed a diversity of functions of Ca2+ ions. Ca2+ may induce a profound conformational change within a single domain, may bridge adjacent domains and thus direct the relative domain orientation and supramolecular structure, or may be involved in carbohydrate and membrane binding.

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1-Carboxyglutamic AcidAmino Acid SequenceAnimalsBinding SitesCadherinsCalciumCalcium-Binding ProteinsCarbohydrate MetabolismEpidermal Growth FactorExtracellular Matrix ProteinsHumansLectinsMolecular Sequence DataOsteonectinJournal ArticleReview

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P Maurer, E Hohenester, J Engel. 1996. Extracellular calcium-binding proteins.. https://doi.org/10.1016/s0955-0674(96)80101-3

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