Interacting signaling pathways controlling multicellular development in Dictyostelium.

R A Firtel

doi:10.1016/s0959-437x(96)80082-7

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Interacting signaling pathways controlling multicellular development in Dictyostelium.

R A Firtel

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Abstract

cAMP functions as the key extracellular signaling molecule controlling Dictyostelium development acting through classic G-protein-coupled/serpentine receptors. Whereas aggregation is controlled by nanomolar pulses of cAMP, a more continuous micromolar signal controls multicellular differentiation by activating a transcriptional cascade via a receptor-mediated but non G-protein-coupled pathway. Potential mechanisms by which extracellular cAMP functions to differentially control aggregation followed by morphogenesis and cell-type differentiation are discussed. This review also summarizes new findings elucidating pathways controlling cell-type regulation in this organism, including signaling cascades mediated by glycogen synthase kinase 3 and cAMP-dependent protein kinase, key regulators of cell-type differentiation in metazoans, and newly identified transcription factors.

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Animals Cell Division Cyclic AMP Dictyostelium GTP-Binding Proteins Gene Expression Regulation, Fungal Genes, Fungal Genes, Homeobox Models, Biological Protein Kinases Signal Transduction Spores, Fungal Transcription Factors Zinc Fingers Journal Article Research Support, U.S. Gov't, P.H.S.Review

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R A Firtel. 1996. Interacting signaling pathways controlling multicellular development in Dictyostelium.. https://doi.org/10.1016/s0959-437x(96)80082-7

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